High Dimensionality

  • Sparse
    • 10^5cells with 5 markers
      • 0.1 \times 10grid; one cubicle only has 1 cell in average. It is too sparse to estimate density in a regular way.
  • No center, no common individuals

N <- 10^4
x <- runif(N)-0.5
y <- runif(N)-0.5

s <- which(x^2+y^2<0.5^2)

plot(x,y,pch=20,cex=1)
points(x[s],y[s],pch=20,cex=1,col="red")
n <- 1:10
r <- 0.5
vol.hypersphere <- pi^(n/2)/gamma(n/2+1) * r^n
plot(n,vol.hypersphere,pch=20,cex=3)