1細胞シークエンス for 癌ゲノム

• この論文から、癌ゲノムのための1細胞シークエンシングを理解するための用語を拾ってみる。その用語の端的な意味が解れば、論文の大意をとることができる
• Single cell sequencing
• evolutionary history of a tumor
• NGS
• heterogeneous tumor, within tumors
• infer, inference vs. estimation
• phylogenetic tree
• most recent common ancestor(MRCA)
• copy number variation
• cluster, clustering
• distance in the tree between the samples
• exome sequencing
• evolutional mutation tree これはこの論文の本体概念
• root (of the tree)
• likelihood
• pairwise mutation orders
• minimum spanning tree (algorithm)
• gene tree algorithm by Gusfield
• perfect phylogeny
• coalescent theory
• sequencing error
• DNA mutation site gene tree これはこの論文の本体概念
• oncogenic tree algorithm by Desper
• causal relationship among copy number aberrations (causative mutations)
• comparative genomic hybridization (data)
• statistical model for inferring pairwise mutation orders
• Bayesian approach
• prior and posterior distributions of mutation orders